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Sunday, September 15, 2013

Another View On Heart Disease by Jeffrey Dach MD

I realize I am doing a lot of blog posts on Heart Disease and the Unified Theory of same as put forth by Linus Pauling. I feel it is an issue that sooner or later will be very interesting to a large number of type 2 diabetics as it is statistics bear out a close relationship between (out of control) type 2 diabetes and heart disease. When you factor in stress, smoking, lack of exercise, genetics, trans fats, high fructose corn syrup and hydrogenated and partially hydrogenated or fractionated oils the link is TOO BIG to ignore.

Try and remember as your read these posts that we are talking about ONE MILLION plus people a year having heart attacks in the USA alone and approximately 60% of those are FATAL.

(I praise the LORD above that HE used traditional medicine including EKG's, nuclear EKG's, Heart Cath's and heart surgery to very possibly SAVE MY LIFE. Without the quadruple bypass surgery and despite my concept of myself as INVINCIBLE and without any symptoms or chest pain, shortness of breath etc. I could have dropped on my nose one day walking down the sidewalk. I UNDERSTAND, RECOGNIZE AND APPRECIATE THAT FACT....I really, really do and I am GRATEFUL FOR THE SURGERY.)

That being said, if the information I have put in the last 10 or 12 blog posts I have done concerning Linus Paulings USA Patent in 1994 for the CURE of heart disease utilizing vitamin C, L-lysine and L-Proline had been WIDELY AVAILABLE AND recognized and discussed with patients over the last 15 or 20 years, I VERY LIKELY would not have needed bypass surgery and my arteries would have been clear. I also have a great deal of respect for the surgeons who do these bypass operations.  I honestly feel the majority of these surgeon's are honest, dedicated, kind, caring, hard working individuals. The same can be said for the cardiologists' and every one of their staff members from the receptionist to the nurses, nurses aides and everyone working in the medical field. My problem lies more with those that are purposefully working behind the scenes to cover up the work done by Linus Pauling and others because of a PROFIT MOTIVE (I.E 30 billion dollars a year from Precription drugs)

I am well aware that Dr. Linus Pauling and Dr. Matthias Rath and others have their critics, however from what I have read most information criticizing the cure of heart disease with supplementation of mega does of Vitamin C, lysine and proline are sponsored by Big pharma or those who have a financial interest in perpetuating that cholesterol is YOUR ENEMY, and everyone needs to be on STATIN DRUGS including school children, etc. I have even read in print where it is being suggested that statins be put in community water supplies. In addition most of these studies I have looked at do NOT follow the recommendations of Linus Pauling or Matthias Rath in doseage requirements. In my most recent post of a study performed and sponsored by Big Pharma, less than 1/16 of the Vitamin C doesage was used to try and disprove that Vitamin C had any redeeming value above the 60 mg dose to prevent scurvy in sailors out to sea for extended periods.

In addition Vitamin C is a nutrient based supplement which your body NEEDS and can assimilate. The same can be said for L-Lysine which is an essential amino acid and L-Proline which is a non-essential amino acid (since your body can make it). Humans unlike animals do not produce their own vitamin C, like animals do. Most drugs including statins come with a LONG LIST of side effects, some of them fatal or crippling in nature. They are also NOT a natural product and readily digested by the human body and therefore alter your digestive tract or do other possible damage to one or more organs such as your liver, pancreas, kidneys etc. (DRUGS are a foreign substance in your system). My understanding is that Vitamin C comes with a warning sign too.......if you ingest too much, you might get diarrhea and if you then back down the amount of vitamin C ingested, the diarrhea goes away. I CAN LIVE WITH THAT. That side effect is what I would personally call the SHORT LIST. If you google Lipitor side effects, you can quickly count TWENTY SEVEN of them in about 12 seconds. The side effects list then has a disclaimer that this list is NOT COMPLETE. I suspect it is because they simply do not know what else it may do inside your body. It is an open ended scenario. By the way, guess what?...........diarrhea is also on the list of side effects with Lipitor. OOPS, I forgot to mention the 1-800-BAD DRUG ads on TV......IF you are a post menopausal female and have been taking lipitor, it just might give you Type 2 diabetes. Better make that short list in 12 seconds 28 SIDE EFFECTS.

Following is another LINK along these lines:

The article is VERY LONG, so I have only copied a portion of it here. It is also VERY INFORMATIVE so I urge you to open the link and read it for yourself. REMEMBER, I am not a doctor, and have no formal medical training of any kind. I am a recent quadruple bypass heart surgery survivor. I am passing along research and information I have found to be fascinating for anyone who would like to have an alternative approach to the status quo statin drugs, blood thinners, cholesterol is your enemy information put out by BIG PHARMA and the medical community at large. You decide for yourself. Dan


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Heart Disease, Ascorbate, Lysine and Linus Pauling by Jeffrey Dach MD
Heart Disease, Ascorbate, Lysine and Linus Pauling by Jeffrey Dach MD

The Steam Roller is Not Joking

Alt description goes hereI once had a conversation with a cardiologist friend of mine in which I casually mentioned the Linus Pauling Theory of heart disease, and the subsequent idea that a non-toxic nutritional supplement program with vitamin C and a few amino acids could prevent and reverse heart disease.  The response from my cardiologist friend was hearty laughter that anyone would even suggest such a nonsensical idea, and surely you must be joking?

left image: courtesy wikimedia, roadroller

My cardiologist friend and the rest of the mainstream medical system has no clue about the steamroller (above image) coming to health care aiming right at the huge profits from diagnosis and treatment of heart disease, a multi billion dollar industry in the US.

The Cardiac Cath Lab and Cardiac Bypass Surgery Program will be flattened, the first casualties of the internet medical information revolution providing information about a safe and cheap supplement program to reverse heart disease called the Linus Pauling Protocol.  Time has come for the old dinosaurs to go.  In the near future, thanks to Linus Pauling, heart disease will become a curiosity of the past, like the disappearance of gastric ulcers after the invention of antacids and antibiotics.

The Linus Pauling Protocol - Vitamin C
Collagen Vitamin C AscorbateVitamin C Deficiency Has  Major Impact on Collagen ProductionVitamin C is required to make a protein called collagen which is the major component of connective tissues.  The lack of Vitamin C is a deficiency disease called Scurvy.

Why is Collagen Important ?
Collagen is the most abundant protein in the body.  It is the  structural protein used to make connective tissues, bones, teeth, hair, and arteries.  Strong collagen is important for a strong body.

Left image: "Unraveling Collagen", Stainless Steel, height: 11 feet Julian Voss-Andreae, Orange Memorial Park Sculpture Garden, City of South San Francisco, CA. 5/10/2006. Courtesy of Wikimedia Commons  

Vitamin C Deficiency Results in Absent Lysine Crosslinking on Collagen
Vitamin C is required for strong collagen.  How does this work? Vitamin C is required for lysyl hydroxylase, an enzyme responsible for attaching the lysine residues together on adjacent collagen strands. (see diagram below) Vitamin C deficiency results in weakened collagen strands caused by disrupted lysine crosslinking. The resulting weakened collagen results in a widespread problems in the connective tissues, bones, teeth, skin, hair, arteries, etc.

Steps in Collagen Synthesis (see diagram below Courtesy of Wikimedia)

How are the fibrils crosslinked?  This is done with Lysine residues (see below diagram)

Fibril Cross Linking with Lysine and Lysyl Oxydase (see diagram below)
Above image courtesy of wikimedia commons  lysyl oxidase.

Above image shows three steps in attachment of two fibrils (collagen strands) by combining two lysine molecules with the help of an enzyme lysine hydroxylase which requires vitamin C.

Full Blown Scurvy - Collagen Falls Apart

In the full blown Vitamin C deficiency disease called Scurvy, the structural elements of the body literally fall apart.  Collagen is broken down and not replaced. The joints wear out, the small arteries begin to crack and degenerate, the skin shows easy bruising and bleeding as small vessels rupture throughout the body, and the teeth may loosen and fall out. 

Linus Pauling: Heart Disease is a Chronic Scurvy Condition

Linus PaulingLinus Pauling was unquestionably the greatest scientist of the twentieth century. All of modern biochemistry and molecular biology chemistry is based on Linus Pauling's work, especially his discovery and elucidation of the chemical bond.  Pauling is the only scientist to be awarded two unshared Nobel prizes.  

Pauling's later years were devoted to heart disease, and in 1989 he published "A Unified Theory of Human Cardiovascular Disease,"  in which he states that atherosclerotic plaques in heart disease are actually part of a repair process, to repair the arterial damage caused by chronic vitamin C deficiency. 

Left Image: Linus Pauling Courtesy of Wikimedia
In essence, Pauling said that heart disease is a manifestation of chronic scurvy, and atherosclerotic plaque is a mechanism evolved to repair or patch blood vessels and arteries damaged by chronic vitamin C deficiency.  Linus Pauling also said that atherosclerotic plaque formation can be prevented or reversed with vitamin C, lysine and proline.  These are nutritional supplements available at any health food store for a few dollars.

Atherosclerotic Plaques Contain LipoProtein (a)
Plaque deposits found in human aortas are made up of a form of cholesterol called lipoprotein (a) also called Lp(a).

Atherosclerotic Plaques Are Found at Maximal Mechanical Stress
Atherosclerotic plaques are not found randomly distributed throughout the arterial tree, rather distribution is restricted to sites of high mechanical stress such as bifurcations, and areas of motion such as the surface of the heart (coronary arteries). In the early 1950's, a Canadian, G. C. Willis, MD, made these same observations, and they have been confirmed by 60 years of coronary and peripheral arteriography at major medical centers.  

Exposed Lysine Crosslinks from Damaged Collagen is Site of LipoProtein (a) attachment and Plaque Formation

LysineImagine stepping on your garden hose a thousand times a day.  You will soon notice cracks in the wall of the garden hose.  This is the same process that happens in the artery.  As these  cracks open up, the collagen strands in the wall of the artery are teased apart.  The triple helix collagen strands are normally bound together with lysine crosslinks which are now teased apart and exposed to the circulating blood stream. 

left Image: Lysine courtesy of WIkimedia 
The Lysine residues look like little flags waving from the damaged collagen strand.  The exposed Lysine strands are available for binding to circulating Lipoprotein (a), a special form of cholesterol that has lysine receptors, and is known to increase heart disease risk.  This attachment of lipoprotein(a) to the free lysine residues of damaged collagen initiates the atherosclerotic process.  Over time, this process builds larger plaque deposits which eventually narrow the inner diameter of the artery causing a blockage, or leads to plaque rupture and thrombosis, a catastrophic event which may cause heart attack or sudden death.

Animal experiments in genetically modified mice which have "knocked out" the lysine binding sites on lipoprotein (a) show a fivefold reduction in atherosclerotic plaque formation.

Can You Make Vitamin C ? No You Can'tAscorbate Vitamin CWe humans cannot make vitamin C in our liver as all other animals do.  We humans had a genetic mutation in our ancestry 50 million years ago which "knocked out" the final enzyme in the hepatic synthesis of vitamin C.  The missing enzyme is called GLO (gulano lactone oxidase).  Primates such as gorillas, chimpanzees and orangutans also share this same GLO mutation and cannot make vitamin C.  In adddition all primates share with humans susceptibility to heart disease.

Above Image Vitamin C, a simple ring structure simikar to glucose, Ascorbate Courtesy of Wikimedia

All Animals Can Make Vitamin C, but the Guinea Pig Can't 

Except for humans and primates, all other animals have the three enzymes in the liver which can synthesize vitamin C from glucose (a simple sugar). One major exception is the guinea pig, which is really a rodent and not a pig,  The guinea pig, for some unexplained reason, shares with humans the identical GLO genetic mutation and also lacks the GLO enzyme just like we do.  This makes the guinea pig an ideal experimental model for human diseases.  By the way, although animals that make vitamin C never get heart disease, the guinea pig which lacks the ability to synthesize vitamin C, also gets heart disease.

Animals That Make Vitamin C,  Don't Get Atherosclerotic Heart Disease 
I though this was worth repeating. 

(note: here I am referring to atherosclerotic vascular heart disease in animals.  Dogs and Cats DO succumb to other common types of heart disease such as cardiomyopathy and heart worm etc.)

Animals That Don't Make Vitamin C, Do Get Atherosclerotic Heart Disease
This should be starting to become clear now.

Animal Scientific Support for the Pauling Unified Theory
Guinea Pig lacks GLO EnzymeAs mentioned above, guinea pigs are especially well suited to study atherosclerosis because guinea pigs are unable to make their own vitamin C, and in addition, they develop atherosclerotic plaques similar to those found in humans.  

Left Image Guinea Pig Courtesy of Wikimedia

G. C. Willis, a Canadian doctor, conducted research with guinea pigs in the 1950's showing that guinea pigs deprived of dietary vitamin C developed atherosclerotic plaques, while guinea pigs given plentiful vitamin C were protected. In addition,guinea pigs fed a vitamin C deficient diet had elevated Lipoprotein (a) levels along with the increased atherosclerotic plaque formation in the arteries.(link)(link)

Similar findings were demonstrated in genetically engineered mice lacking the GLO enzyme. The GLO deficient mice fed a vitamin C deficient diet developed atherosclerotic plaques in the aorta with characteristic deranged collagen crosslinking. GLO deficient mice fed vitamin C were protected. (link)

Human Studies Suporting the Linus Pauling Theory
Optometrist, Dr. Sydney Bush's retinal artery observations support the Pauling theory.  Using modern equipment to non-invasively photograph the retinal arteries of the eye before and after Vitamin C supplementation in humans, Dr. Bush has documented reversal of atherosclerotic plaque with Vitamin C supplementation.(link)

Coronary Calcium Score studies also support the Pauling Theory with favorable results after treatment with Vitamin C and Lysine. 

Anecdotal case evidence of reversal of heart disease can be found in the medical literature and documented in Owen Fonorow's book (see image below).  In these cases, advanced heart disease regresses after supplemention with the Linus Pauling Protocol.  This is highly significant because the natural course of heart disease is progression, and any intervetion that alters the natural course of a diseae process is highly significant.

Message boards are a source of anecdotal cases reports supporting the Linus Pauling Protocol.   The Track Your Plaque Message Boards have documented many cases of regression of atherosclerotic disease with protocols which include vitamin C  as well as other nutritional supplements. (There is a modest membership fee for TYP) 

Why no drug company sponsored double blind placebo controlled studies? Since there are no patents involved for natural supplements, and no drugs involved, no drug company would ever invest the 250 million dollars to fund such a study with no potential for financial return.  

The Physician's Health Study - Don't Waste Your Money On Vitamins !!

Using public funds, the NIH (National Institute of Health) funded a large study called The Physicians' Health Study II which evaluated Vitamins C and E in heart disease and was published Nov. 9, 2008 in JAMA by Howard D. Sesso.  The study found that Vitamin C and E did not prevent mortality from heart disease, results which are completely opposite to massive previously published research and anecdotal case reports.  

A closer look shows a few glaring errors in study design.  The Linus Pauliing Protocol was not followed.  The dosage of vitamin C was set too low, at one tenth the dosage recommended by the Linus Pauling protocol, and lysine was not provided.  While the Sesso study showed no mortality benefit, many previous studies such as the Enstrom Study showed a striking 40% reduction in all-cause mortality over 6 years from the same 500 mg daily vitamin C dosage. The Paul Knecht studyshowed a 25% reduction in Heart Disease risk with daily 700 mg Vitamin  C.   Two previous studies from Japan and Finland showed that Vitamin C reduces risk for stroke, another atherosclerotic disease.  There are many more like these.

Since favorable results would be financially destructive to the drug and hospital industries, a cynic might suggest that vested interests were at work in Sesso's study intending to discredit vitamin C (as documented many times in the past with examples of corporate influence in medical research).  It is not difficult to design a medical study to fail.  I regard this as merely another example of the information war waged by corporate mainstream medicine against natural medicine.

Enstrom Study, 500 mg Vitamin C Reduces Mortality 40% over 6 years
Enstrom showed that increasing vitamin C intake had a dramatic 40% reduction in mortality benefit which exceeds any statin drug study ever conducted.

Linus Pauling Protocol For Prevention and Reversal of Plaque
If heart disease is chronic scurvy, caused by chronic vitamin C deficiency, then it makes sense to supplement with vitamin C in the amounts needed to make strong collagen and prevent arterial damage from mechanical stress.

In addition, Pauling devised a clever yet simple method to address the issue of Lipoprotein (a) attaching to the lysine residues on the damaged collagen fibers in the arterial wall.  He recommended supplementing with 2-4 grams of lysine per day.  The additional lysine in the blood stream attaches to the receptor sites on the lipoprotein (a) molecules, inactivating the lipoprotein(a) and preventing it from attaching to the arterial wall.  This prevents the initiation of the atherosclerotic process.  In addition, Vitamin C and Lysine are both important precursors for building strong collagen which makes strong arteries.

In addition to Lysine, some of the collagen crosslinking is done with another amino acid called Proline, so proline was also added to the treatment protocol.
Where to Read About the Linus Pauling Protocol:

Above image, Cover of Linus Pauling Protocol Book courtesy of Owen Fonorow.
Read more about the Linus Pauling Protocol in this new book (above image): Practicing Medicine Without a License by Owen Fonorow.(link)(link)

Owen Fonorow is perhaps the single most dedicated person devoted to the 1992 Linus Pauling Protocol for prevention and reversal of heart disease.(
link)  A patent for the Linus Pauling Protocol was issued in 1994.(link)  In 1996, a CAT scan coronary calcium score study validated the protocol showing a 15% reversal of calcification indicating reversal of coronary artery disease.(link Another excellent book on the subject of Vitamin C and heart disease is, Stop America's #1 Killer by Thomas Levy MD, JD. 2006 (link).  To read more on the Linus Pauling Protocol, see this short four page booklet by Owen Fonorow.(link) Or, read this excellent article by English and Cass.(link)

What is the Linus Pauling Protocol?

L-ascorbate (Vitamin C) 5-6 grams a day in divided doses
L-Lysine 5 grams a day in divided doses
L-Proline 2-3 grams a day in divided doses

These supplements can be obtained at any the health food store as tablets or capsules for 40 to 50 dollars a month.  A convenient powder form can be obtained at 
Tower Laboratories.  They have a product called Heart-Tech  which provides the Linus Pauling Protocol in powder form.  There is also the Vitamin C FoundationCardio-C which provides 2500 mg vitamin C and 2500 mg lysine per serving plus 500 mg proline. (link).

Vitamin E, Good or Bad, Yes or No, Blessing or Curse?  

Steve Hickey and Hilary Roberts come right out on page 167 of their book, and make the statement, "Vitamin C and Tocotrienols can reverse coronary artery disease".  They would add the Tocotrienol form of Vitamin E to the Linus Pauling Protocol.  Regarding heart disease, and atherosclerotic vascular disease, the authors state that "on the available evidence, the combination of Vitamin C and Tocotrienols could be curative with no known harmful effects."  For a more complete discussion of Vitamin E, see my article, Vitamin E, Curse or Blessing? by Jeffrey Dach MD.
Opposition to the Linus Pauling Protocol by Mainstream MedicineCoronary bypass surgeryIf you are facing the prospects of coronary artery bypass surgery (left image), you might ask the obvious question: Why hasn't my cardiologist told me about this information and started me on the Linus Pauling Protocol?  

Most cardiologists either don't know about it or ignore it because of the information war going on between mainstream medicine and natural medicine.  Cardiologists read medical journals which regularly run incorrect and biased articles saying Vitamin C is useless for prevention and reversal of heart disease, such as the Nov 9 2008 Sesso study. (link). 
Above image: coronary artery bypass operation courtesy wikimedia. 

Diagnosing and treating heart disease with expensive tests and procedures such as coronary angiography, angioplasty, stenting and bypass operations is the most profitable part of hospital big business.  That's why hospitals compete and fight with each other over the rights to expand and build larger cardiac cath labs and cardiac bypass operation programs.  These programs are huge money makers for the national hospital system.

What would happen if there was a cheap and effective way to reverse and prevent heart disease, (ie. the Linus Pauling Protocol)?  Heart disease would become an uncommon illness.  With fewer heart patients to treat, the multi-million dollar cath labs and cardiac bypass programs at your local hospital would become obsolete and disappear.  This would be a financial catastrophe for mainstream medicine.

Hospital Expansion for New Cardiac Cath Lab and Open Heart SurgeryNo More Construction Cranes?

With so much money and vested interest at stake, you can imagine why it is not prudent for a cardiologist to bring up the benefits of the Linus Pauling Protocol in friendly conversation while lunching in the Doctor's Dining Hall.  That would be an instant ticket off the medical staff roster and out the hospital door, and the end of a lucrative cardiology practice.  What cardiologist in their right mind would do that?  It is easier for the mainstream cardiologists to simply laugh it off as a joke and go back to the cath lab, do more procedures and make some money to pay their bills. 

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