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Showing posts with label TESTOSTERONE and Type 2 Diabetes. Show all posts
Showing posts with label TESTOSTERONE and Type 2 Diabetes. Show all posts

Friday, December 20, 2013

MORE On Boosting Testosterone In Older men While Blocking Estrogen

As a follow up to my last post on the damaging effects of estrogen in older men, here is some valuable information on combating estrogen levels.

I am going to post a link from Jason Ferruggia on lowering estrogen levels in men while at the same time boosting testosterone. This information is a good follow up to my last post.

Here is the nutrition label from Athletic Greens:

athletic green ingredients


Dan

http://jasonferruggia.com/how-to-lower-estrogen-levels-in-men/

EXCERPTS:


How to Lower Estrogen Levels in Men


 
lowerestogen 300x207 How to Lower Estrogen Levels in MenHow to lower estrogen levels in men is a hot topic these days since it seems to be something that so many males suffer from.
Seinfeld fans will undoubtedly never forget the episode in which Frank Costanza and Kramer invented the mansierre, which was a bra for men with excessive breast development. While we all laughed hysterically some people were just the slightest bit uncomfortable because the reality is that an inordinate number of men have “moobs,” or man boobs.
This is often due to excessively high body fat levels. But it can also be due to high levels of estrogen. Having high estrogen can not only cause you to gain body fat in the chest and lower abdominal area but it can lead to numerous health issues and diseases. Unfortunately more and more males are suffering from increasingly high estrogen levels and this is leading to the continued feminization of the male species as we know it. Today, the average male has a testosterone level that is 15-50% (depending on the study you read) lower than it was 50 years ago. This is an epidemic, my friends.
It has to stop now before it’s too late.
So I’ve compiled a list of 13 ways that will help answer the question How to Lower Estrogen Levels in Men. Check it out below…
By following this advice you will hopefully eliminate your need for ever having to call up Kramer and Frank for one of their prized inventions.
1) Don’t eat fake foods. This means most foods that come out of a box, bag or can should be off your list. The rare exceptions are oats, brown rice and the occasional serving of legumes. Basically, if a cavemen couldn’t eat it, you shouldn’t eat. All the chemicals and artificial junk that they put in most foods these days can lead to increased estrogen levels and numerous other health problems.
2) Avoid eating and drinking out of plastic as much as possible. This has been linked with increased estrogen levels.
3) Eat only organic, pesticide and chemical free produce, preferably purchased from a local farmers market. Pesticides and herbicides have been shown to increase estrogen levels.
4) Avoid all meat and dairy unless you are 100% sure that it is drug free and organic. All of the drugs and hormones that go into most animal and dairy products will wreak havoc on your body, dramatically boost estrogen levels and lead to heart disease and cancer. Also be sure to eat only beef that is from grass fed and not grain fed cows. I personally order from US Wellness Meats and highly recommend their services and products.
5) Avoid all commercially made protein powders for the same reasons listed above. If your whey protein comes from a cow that has been fed grains and pumped full of drugs there’s a good chance your estrogen levels will go up from consuming it. That’s why I only recommend the following three brands of protein powder:
one world whey 188x300 How to Lower Estrogen Levels in MenAll Pro Science Grass Fed Whey- Click the link for a free sample.
One World Whey- The best tasting and easiest digesting protein I’ve ever used. As an added benefit, it’s made from raw milk, which makes it significantly better for you.
Sun Warrior- For those that don’t want whey this is an outstanding, organic protein made from sprouted brown rice.
6) Limit your consumption of fish and be sure that it is fresh catch and from clean water sources. Unfortunately we have destroyed and polluted many of the lakes, oceans, streams and rivers on the planet and because of that a lot of the fish we consume these days is loaded with PCB’s and dioxins that you should really avoid as much as possible.
If you take an essential fatty acid supplement (as you should) make sure that it’s from clean sources and uncontaminated, like Pro Grades Krill Oil.
You should also support clean water laws and organizations like Waterkeeper.
7) Only drink purified water. Our water quality continues to worsen all the time and is filled with numerous toxins and estrogenic compounds. Surprisingly, NYC has great water quality. Other places are not so fortunate.
8] Consume citrus fruits regularly. These have been proven effective in the fight against estrogen.
9) Eat lots of cruciferous vegetables such as broccoli and cauliflower. These have also been shown to have anti estrogenic properties.
An outstanding product, that I and all of my clients take daily is Athletic Greens. It has ample amounts of cruciferous veggies and citrus fruits in it along with several other organic compounds. It’s at the top of my recommended supplement list.
10) If you must drink alcohol try to avoid beer as much as you can because it is highly estrogenic; thus the acclimation of a beer belly. Red wine is a far better choice and may actually be anti estrogenic. Personally, I prefer and recommend vodka.
11) Eat a good amount of organic nuts and seeds. A high intake of organic nuts has been linked to increased virility in men.
12) Lose excess bodyfat. Nothing will help prevent the conversion to estrogen any more effectively than losing bodyfat. It’s absolutely essential for males to get their bodyfat levels under 15% and keep them there if they want to be healthy and win the war against estrogen. That means cut your carbs and your junk food and get out there and start sprinting two or three times per week.
13) Be sure to only train with short, high intensity workouts like those found inMuscle Gaining Secrets. This won’t lower estrogen levels but it will increase your testosterone levels. If you have higher testosterone chances are you’ll have lower estrogen.

Monday, May 20, 2013

Testosterone Boosting Exercise

I came across this website today and thought I would pass this one while my mind is on boosting my own testosterone. Being 65 years old and NO spotters at home to work out with and to top things off a guy who suffered from an L4,L5 and S1 back problem three years ago, I am HESITANT to dive into HEAVY LIFTING EXERCISES to try and boost testosterone. You older guys can relate to this.

I spent around 6 or 7 months three years ago in a LOT of pain and Praise the Lord, I avoided back surgery. I did end up after a lot of prayers, trips to the chiropractor and the physical therapist having two nerve block shots with a hydroscopic needle which miraculously took away my pain and it has never come back. I thank the good Lord above for that. Since then I am faithful in doing stretching exercise and abdominal strengthening exercises every day.

I am going to post a link here which shows 6 of the best exercises you can do to boost testosterone. Remember there is a link between type 2 diabetes, heart disease and LOW testosterone. It isn't all about your libido.

One thing that interested me on this site was the concept of SPRINTING for short bursts during your walk or normal run if that is part of your regimen. INTENSE short bursts of sprinting or I would also presume INTENSE BURSTS OF WALKING AS FAST AS YOUR LEGS WILL CARRY YOU FOR 10-20 SECONDS AT A TIME can prove very beneficial.

I have started doing the "Interval Fast Walking" routine when I walk. I am a little leery of even taking up the running and sprinting again because of the previous bout of back problems. If L4, L5 and S1 bring back memories for you, you will not want to go there again if possible.

IF you can handle the stress on your back and your system and want fast results, then you can follow this guys advice to the letter. If you are gun shy of jumping in head first, then work your way into it and perhaps substitute the fast/normal interval walking in place of SPRINTING. In my case adding the Testofen supplements will be a bonus.

Dan

In any event here is the link:

http://getfitguy.quickanddirtytips.com/6-ways-to-increase-testosterone-with-exercise.aspx

EXCERPTS:



by Ben Greenfield
Testosterone is a steroid hormone that helps you increase lean muscle mass and bone density – and beyond simply helping you have a nice body, it’s also crucial for good health! Low levels of testosterone, in both men and women, can lead to a number of serious health conditions, including increased risk of depression, low sex drive, obesity, and osteoporosis.


Men with low testosterone tend to have higher rates of heart disease, depression, and even dementia – and a decrease in testosterone levels in women can lead to a loss of muscle mass and weight gain (especially when paired with the rising levels of estrogen that you learned about in my episode onHormonal Imbalances and Weight Gain).
Although there are entire industries built up around herbal and pharmaceutical pills, capsules, lotions, injections, super foods, and other methods for increasing testosterone, in this episode you’re going to get 6 simple strategies for increasing testosterone without actually swallowing any questionable supplements.
6 Ways to Increase Testosterone With Exercise

Tip #1: Sprint
Multiple studies have shown that you can boost your testosterone levels by sprinting. In one study, testosterone levels increased significantly for people who performed a series of very short (but intense) 6-second sprints – and testosterone levels remained high even after those people had fully recovered from the sprint workout.
So how can you implement the strategy of sprinting to increase testosterone? Try performing several sprints on the treadmill after you have lifted weights at the gym, or just head out into the backyard, a park, or your neighborhood block and do a few sprint repeats on your days off from weigh training. You can even do your sprints on a bicycle or elliptical trainer. Try to include 5-10 short sprints when you do a sprint workout, sprint no longer than 15 seconds, get full recovery after each sprint (generally 3-4 times longer than you actually sprinted), and do a sprint workout 2-3 times a week for optimal results.
Tip #2: Lift Heavy Stuff
While you can do high reps with low weights or low reps with high weights,studies have shown that it definitely takes heavy weights to significantly boost testosterone. Full body, heavy exercises like squats, deadlifts, bench presses, and Olympic lifts should ideally be used, at 85-95% of your 1RM (or one repetition maximum). You need to do 2-3 full body weight lifting workouts per week to get good testosterone-boosting results (in tip #5, I’ll give you a sample workout).
If you're a beginner or new to weight training, don’t let this concept of heavy lifting scare you away. You can simulate many of these exercises on weight training machines until you’re strong and skilled enough to perform the free weight barbell or dumbbell versions.
Tip #3: Use Long Rest Periods
Scientists have studied the effects of very short rest periods on testosterone and found that longer rest periods of around 120 seconds between sets are better for building testosterone (although you can still build other hormones, such as growth hormone, with shorter rest periods).
Considering what you’ve just learned about lifting heavy weights, this makes sense – since the shorter your recovery periods, the less weight you’re going to be able to lift. However, it can seem like a waste of time to be sitting on your butt for 3 minutes between each exercise.
So if your goals are to increase testosterone, I recommend that you maximize your time at the gym by doing alternate activities during these long rest periods, such as stretching, or better yet, exercises that don’t stress the same muscles you just worked.
For example, you can do one heavy set of bench presses, recover for just 30-60 seconds, then do one heavy set of squats. Go back and forth until all your sets are done, and you’ll get twice as much done in half the time, while still getting the testosterone boosting benefits of lifting heavy and long rest periods.
Tip #4: Do Forced Reps
To do a forced repetition, you perform a weight lifting exercise for as many reps as you can, and then have partner (a “spotter”) assist you with completing several additional repetitions (anywhere from 1-5 extra reps).

Research shows that this type of forced rep set generates more testosterone than simply doing as many reps as you can do by yourself.
It’s best to do forced reps with a multi-joint, large motor movement exercise. For example, you can do a warm-up set of barbell squats, then, with a partner, a personal trainer, orsomeone you ask at the gym to help you, choose a weight that allows you to do 5-6 repetitions on your own, but requires an assistant to get another 3-4 reps done after that, for a total of 8-10 reps. You can repeat this for anywhere from 2-6 sets.
While you don’t need to perform forced reps for every workout or set that you do, if you’re trying to increase testosterone, it can be especially helpful to do your last set of any exercise as a forced rep set.
Tip #5: Use Your Legs
In another study that investigated the hormonal response to weight training, participants were split into an arm-only training group and a leg-plus-arm training group. Testosterone increases were significantly higher in the group that added lower body training to their upper body training.
While it can be tempting, especially for guys, to focus on exercises like biceps curls and bench pressing, you’ll notice far better results for lean muscle mass, energy, sex drive, and fat loss when you include multi-joint leg exercises such as lunges and squats into your regimen.
So here’s an example of a full body workout you could do 3 days per week to boost testosterone:

Warm-up

4 sets of 8 repetitions bench press, paired with 4 sets of 8 repetitionssquats.

4 sets of 8 repetitions deadlifts paired with 4 sets of 8 repetitions pull-ups.

6 sets of maximum 10 second sprints.

Cool-down
Tip #6: Avoid Chronic Cardio
Long endurance sports such as cycling seem to lower testosterone in the same way that weight lifting and weight training seem to increase it. For example, one 2003 study found that testosterone levels were significantly lower in cyclists than age-matched weightlifters, or even an untrained control group. Some researchers have even concluded that this type of low testosterone in endurance athletes is an adaptation that gives cyclists or runners a competitive advantage – since the extra muscle mass from testosterone would probably slow you down.
So if you’re trying to boost testosterone, avoid long jaunts on the treadmill, and accept the fact that if you’re going to run marathons or do Ironman triathlon, you may have to settle for slightly lower testosterone levels.
If you have more questions about how to boost testosterone with exercise, or other testosterone-enhancing questions, then join the conversation atFacebook.com/GetFitGuy!

Testofen From Swanson Health Products

I received my two month supply of Testofen from Swanson vitamins in the mail today and officially started on two capsules a day on 5/20/2013.

I will post my results in 60-90 days after giving the product a fair trial period. Here is the bottle label with ingredients:


Supplement Facts

Serving Size 1 Capsule
Amount Per Serving% Daily ValueTestofen® Fenugreek SeedExtract (Trigonella foenum-graecum) (standardized to 50% fenusides) 300 mg *



*Daily Value not established.


Other ingredients: Rice flour, gelatin, may contain one or both of the following: magnesium stearate, silica.

Suggested Use: As a dietary supplement, take one capsule two times per day with water.

WARNING: Do not take this product if you are pregnant or nursing.

Testofen® is a registered trademark of Gencor Pacific, Inc.

(My Input)

Customer reviews from Swanson are MIXED, however in most cases the reviews I read were based on how people feel. There were not any reviews where people had their testosterone levels measured with a blood test BEFORE and after being on testofen for 60 to 90 days. I feel that opinions based on how one feels after 60-90 days do have some merit, however without testosterone levels being tested to show before and after results, opinions are just that...OPINIONS.

Perhaps a better review would be the one I am posting here from Gencor which is the company that developed the various testofen supplements. Here is a LINK to that information:


EXCERPTS:


Benefits and market opportunity

Testofen® is a fenugreek extract standardized for 50% Fenuside™.

Testofen is the branded name for Gencor’s fenugreek extract. Fenugreek is a well-known, versatile herb that contains over 100 phytochemical constituents, including Furostanol Saponins and Steroidal Saponins. While fenugreek has multiple health applications, the active constituents included in Testofen have been shown to boost testosterone levels an thereby increase libido, lean muscle mass and immune functions. The group of saponin glycosides that Testofen is standardized to is named Fenuside.

After age 30, most men begin to experience a natural and gradual decline in testosterone levels, which can result in reduced drive and libido and a slow loss of muscle tone and definition. Most of the testosterone found in men is bound to the Sex Hormone Binding Globulin (SHBG) and Albumin. Only 2−3% of the testosterone present in the human body is typically in a free state. Testofen has been shown to increase free testosterone, up to 98 percent, in an eight-week trial (see below).*

Incorporate Testofen in product formulations designed to support healthy sexual function in adult males.*

Clinical research

Both animal and human clinical studies have been conducted on Testofen®.

Animal study

Study results: The 2010 study of Testofen on the reproductive systems of rats demonstrated that Testofen supported an increase in intracarvenous pressure, which led to healthy erectile functions.* Improvements in libido and muscle mass were also measured.*

Citation: Urmila Aswar et.al, 2010. Effect of Furostanol Glycosides from Trigonella foenum –graecum on the reproductive system of Male Albino Rats. Phytotherapy Research, 24, 1482–1488.


Human study on adult male libido

Study result: A six-week double-blind, randomized, placebo-controlled clinical study was conducted in Australia in 2009 on 60 healthy adult males. A formulation containing Testofen as a major active ingredient showed a statistically significant increase in the sexual function, performance and satisfaction of the active group.* Study used the DISF-SR index, in addition to quality of life measures such as perceived muscle strength, energy levels, and well-being.


This study used the DISF-SR index (the lead index in studies of sexual health) and measured the following variables:
Sexual cognition
Sexual arousal
Sexual experience
Ability to have an orgasm
Quality of sexual performance
Recovery time following sexual activity
Overall libido
General energy levels

Testofen showed statistically significant increases in DISF-SR parameters (including sexual arousal and orgasm). In addition, Testofen had a positive effect on 3 quality of life (QOL) parameters:
Muscle strength
Energy levels
Overall well-being

Citation: Steels, E., Rao, A. and Vitetta, L., 2011. Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum-graecum Extract and Mineral Formulation. Phytotherapy Research, Vol. 25, 1294–1300. doi: 10.1002/ptr.3360


Human study on free testosterone levels and performance

Study Results: A double-blind, randomized, placebo-controlled human clinical study of 60 subjects was conducted using Testofen as the sole ingredient. The active group demonstrated the following statistically significant results:
Significant anabolic activity as evidenced by BUN reduction (p<0.05) compared to placebo*
Significant increase in free testosterone (p<0.05) compared to placebo group*
Increased immunity (p<0.003) compared to placebo group*
Significant reduction in Serum Creatinine levels (p<0.02) compared to placebo group signifying Creatine uptake and recycling in muscle cell*
Significant increase in prolactin (p<0.04) compared to placebo group, however, this increase is within physiological limits for men*
Significant decrease in body fat compared to baseline*
Maintenance of muscle size despite maintaining overall weight and reduction of body fat*


Citation: Wankhede et. al., 2006 “Effect of Testofen on safety, anabolic activity and factors affecting exercise physiology.” To be published.


(IN ANY EVENT) I recently had my testosterone tested as part of my ongoing lab tests connected with type 2 diabetes.

I posted my last two tests on this BLOG and have no "Dog in the fight either way". I will NOT go on the Androgel 1.62% again because of side effects of which the main one was dramatically increased blood pressure readings while taking it with very little real world increase in testosterone.

SEE MY POST ON 3/14/13 ENTITLED: CholesLo works - look at my numbers. My testosterone was
272 when my last test was done and I started taking testofen from Swanson TODAY 5/20/2013. I will POST my results in 60 or 90 days along with my opinion and view on increased energy, muscle mass etc. In the 3/14/2013 post showing blood lipid profile numbers from taking a product called CholesLo my testosterone numbers are DISMAL at best on both 10/26/12 and again when recently taken  later in March  2013. My results whatever they may turn out to be will reflect dietary and exercise changes also.

EXCERPT from 3/14/13 post:

Here are the numbers:

10/26/12 Lab Work Numbers:

  • Triglycerides  (359)
  • Cholesterol    (183)
  • HDL               (31 )
  • LDL               (80 )
  • Testosterone  (248)

NEW Numbers for latest test (71 days on CholesLo):

  • Triglycerides (216) for a 143 point drop or 40% LESS
  • Cholesterol    (152) for a 31 point drop or  16.9% LESS
  • HDL (good C.)  (33) UP 2 points or 6.45% BETTER
  • LDL (bad C.)    (76) for 4 point drop or 5% LESS
  • Testosterone  (272) for 24 point increase or 9.67% better

MY next readings will be sometime probably around the end of July. I walk virtually every day, and I do squats with the dumb bells and overhead  pushes to exhaustion with 20 pound dumb bells, along with abdominal exercises and stretching.

On the alternate days, I do 75-100 push ups and on every day I do a few pull ups and chin ups. I have also added canned salmon, more eggs, more nuts and take a full range of supplements that include more than adequate amounts of B6, B12, Zinc, Magnesium, Vitamin D3, fish oil etc.

Based on what I have read concerning testofen, I feel 60-70 days of taking two caps a day along with the exercise etc. should show some results.

Look for my numbers again around the first part of August.

Dan

Theodore Roosevelt
“I believe you can and you're already there”
― Theodore Roosevelt


Sunday, May 12, 2013

Benefits of Adequate Testosterone Levels

Why all the fuss over testosterone levels as we age? What is the role of testosterone in the body anyway and do we really need to keep track of our levels as we age and especially if we are type 2 diabetics?

I have previously done blog posts on the link between LOW levels of testosterone and the development of Type 2 Diabetes. There is also a link between low T levels and the development of heart disease.

I think if you are going to pursue increasing your testosterone levels you need to:

Pursue a complete program including eating testosterone building foods, doing more aerobic and especially weight bearing exercise. Squats with the dumb bells, along with bench presses, push ups, pull ups, chin ups, mountain climbing, interval fast/normal walking and running, doing short burst of intense running, along with taking the right supplements such as TESTOFEN, or one of the products including testofen such as Ageless male, Testoril etc. I like to do three sets of squats with the dumb bells 3 or 4 times a week to exhaustion.

I would STAY AWAY FROM THE DRUGS AND THE GELS AND CREAMS. Why?.......last time I looked one of the inescapable side effects was "Testicular Atrophy"......YOU DON'T want that.

Blood pressure a little high? TRY green smoothies based on celery first, along with aerobic exercise, losing weight etc. FIRST before simply going on a prescription drug for blood pressure with its own list of deadly side effects.

No heart disease yet, however the doctor urges you to go on LIPITOR and/or CRESTOR, and/or some other drug as a preventive measure? I urge you to to do your own research on the dangerous side effects of Statins FIRST.

PLEASE check out the writings and research of ROB THOBURN on testosterone and the best way to boost yours:

http://robthoburn.wordpress.com/2011/02/05/fenugreek-increases-testosterone-and-it-smells/

(MY INPUT):

Testofen as offered by Swanson Health Products looks to be a best buy for increasing testosterone. You may also want to look into cycling tribulus terrestis, maca, DHEA 25mg, Ginko Biloba, long jack etc. along with testofen. I urge you to visit several websites that concern themselves with cycling (on and off again) use of these other products.

You can also look at products like Ageless Male and Testoril which are a lot more expensive if you are already taking a decent multiple nutrient program, exercising and eating right.

What should your testosterone levels be? I have seen charts for adult males from 300-1200 ng/dl and others starting at 366 for the LOW end number. A simple blood test done along with your normal blood lipid profile can be ordered by your diabetes doctor. You should also run your iodine levels once in a while.

Here is some further information on T Levels:

http://www.livestrong.com/article/222182-what-is-the-range-of-testosterone-levels/

EXCERPT:


TESTOSTERONE PRODUCTION

Around 95 percent of circulating testosterone is produced by the Leydig cells in the testes, although the adrenal glands also produce the hormone and its precursors. Testosterone is synthesized from the precursor molecule cholesterol, which goes through a complex reaction pathway producing several intermediate molecules on the way. Testosterone production occurs in the Leydig cells under the control of another hormone called luteinizing hormone. This causes an increase in the number of Leydig cells and an increase in the level of testosterone that they produce in puberty and throughout life.

AVERAGE TESTOSTERONE LEVELS

Testosterone can be measured in the blood in nanograms per deciliter. The first time testosterone is produced is in the first two months of life where levels can reach
300 ng/dL, followed by a steady rise until 6 months. This is followed by a sharp drop in levels until puberty is reached, when testosterone levels rise until adult levels of 300 to 1,000 ng/dL are reached around age 16. TheNational Institute of Health states that the average testosterone levels in adult males is 700 ng/dL, with the healthy range between 300 and 1,200 ng/dL. In adult females, it should be between 30 and 95 ng/dL.
DAILY TESTOSTERONE FLUCTUATIONS

Within an individual, testosterone levels in the blood can vary 10 percent to 15 percent from one moment to the next. Levels are typically higher in the morning. Levels can also fluctuate during the day because of periodic testosterone secretions that occur about every seven hours. The increased levels of secretion are modest and so the rise and fall of blood hormone levels as a result of this are also minor.
TESTOSTERONE BINDING PROTEINS

One major factor determining blood testosterone levels is the amount of free testosterone compared to bound testosterone. The hormone is normally bound to a sex hormone-binding globulin (SHBG), which is produced in the liver and prevents the testosterone from being metabolized as soon as it enters the blood. However, this means that bound testosterone travels around the blood in an inactive form. Only when testosterone is free in the blood can it perform its biological tasks, yet only 1 percent to 3 percent of testosterone is unbound in the blood. A decrease in the SHBG levels will result in higher blood testosterone levels. It is also known that variations in the testing methods can result in a variation of 33 percent in the levels of testosterone found in an individual. These factors should be taken into account when performing a testosterone measurement. If you have concerns about your testosterone levels, consult your physician.
Dan




Fenugreek (vs.) Testofen For boosting Testosterone

While up in the Berkshires recently I picked up a couple of bottles of fenugreek capsules from GNC. Each bottle contains 120 capsules of whole herb fenugreek seed (Trigonella Foenum-Graecum). I was actually looking for a product with testofen in it which is fenugreek extract, which they had in the form of "Ageless Male" for $35.00 a bottle for a one month supply.

Is there any value at all from taking The whole Herb caps from GNC to boost testosterone levels? There are different websites saying YES and..........no. The truth I think lies somewhere in between.A supplement researcher by the name of Richard Kreider PhD of Texas A&M University did a study involving a "purported aromatase and 5-alpha reductase inhibitor, "which turns out to have been fenugreek".

For 8 weeks, 30 YOUNG Male subjects received either a capsule containing 500 mg of fenugreek or a placebo while following a supervised resistance exercise routine. The fenugreek extract was standardized for "grecunin" and supplied by the Indus Biotech of India. I am NO SURE of exactly what grecunin actually is, so can't comment on it.

In any event over the course of the study, total and bioavailable (free) testosterone increased 6.57% and 12.26% respectively, in the subjects taking fenugreek. Estradiol and DHT levels also increased 25.5% and 6.10% respectively. Though not significantly, NO changes in hormone levels were found in the placebo group.

http://robthoburn.wordpress.com/2011/02/05/fenugreek-increases-testosterone-and-it-smells/

EXCERPT:

As explained in my recent post about boron, the enzyme aromatase converts testosterone into estradiol, whereas 5-alpha-reductase (5-AR) converts testosterone into DHT. Thus, you might think that because estradiol and DHT increased in this study, albeit not significantly, the fenugreek supplement didn’t work. The authors seemed to come to a different conclusion, stating, “estradiol decreased 9.64% from Week 0 to Week 4 before rising above baseline values by the conclusion of the 8-week study. Because of a significant increase in total and bioavailable testosterone without a corresponding [significant] increase in estradiol and DHT, we conclude that the [fenugreek extract] successfully, but incompletely, inhibited aromatase and 5-α reductase activity.”

The researchers also measured changes in body composition. While the fenugreek extract did not change fat-free mass, subjects receiving it did experience a reduction in fat mass of 1.77% vs. 0.55% in the placebo group. Granted, such changes may not be all that significant to you in the real world, but they were statistically significant here in the laboratory. The fenugreek supplement was found to have no significant effects on strength.

The authors drew an important conclusion, one worth keeping in mind when you walk through your local sports supplement store in search of a “testosterone booster”:


“AIs [aromatase inhibitors] marketed by nutritional supplement companies claim that these products increase androgen levels similarly to anabolic steroids while simultaneously suppressing estrogen levels. The current data, along with those from our previous work (Willoughby et al., 2007), support this notion to some extent, because we saw increases in total and bioavailable testosterone accompanied with minimal change in DHT and estradiol. Conversely, as our data suggest, an increase in endogenous testosterone levels does not always translate to an increase in muscle hypertrophy and strength. It is likely that the increase in endogenous testosterone levels from the experimental supplement did not affect androgen-receptor expression or the interaction between testosterone and an androgen receptor, which provides a possible explanation of why fat-free mass and strength did not increase more than in the PL group in our investigation. Thus, these data support the notion that elevated levels of testosterone within physiological levels have no influence on muscle strength in strength-trained young men.”

Summary

Most people taking a supplement like the one studied here will do so in the hope that it will provide not merely a change in testosterone, but also some downstream benefit: a change in body weight, body fat, muscle size, strength, libido, energy, mood, etc. What this study suggests is that supplementation with this particular fenugreek extract may allow young, healthy resistance-exercising males to lose slightly more body fat than would be the case if they took a placebo.



My (OWN Limited research)  has shown me that TESTOFEN is the better product for boosting testosterone levels with few if any side effect compared to the various gels such as Androgel 1.62 etc. The Ageless male is a better product than the Fenugreek whole herb caps as it contains other ingredients. here is a LABEL from Ageless male:




In regards to Ageless male, I already get more than adequate levels of B6, magnesium and Zinc and can buy a TESTOFEN extract product from Swanson Vitamins for around $15 a month as opposed to $35 for Ageless male from GNC.

TESTOFEN unlike other fenugreek prodcuts available today, contains HIGH concentrations of a specific group of saponin glycosides isilated and characterized exclusively by Gencor scientists. These compunds called fenusides, are the subject of ongong research which Gencor believes will continue to support fenugreek's testosterone promoting benefits.

Here is a link to Swanson's TESTOFEN product which i feel is a GREAT value in the marketplace right now for those like myself who will NOT go back on any other gels and creams etc because of the side effects.

http://www.swansonvitamins.com/swanson-ultra-testofen-fenugreek-extract-300-mg-60-caps







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Product Label

Swanson Ultra
Testofen Fenugreek Extract


69 Reviews
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SWANSON$14.99Item:SWU461Availability:In StockCaps Size:O, Pill Size GuideSize:300 mg 60 Caps


Testofen--a unique, standardized Fenugreek extract
Features testosterone-supporting fenusides
Studied for its effects on libido in men & women
Fenugreek is nothing new. But Testofen isn't your average Fenugreek. It's the result of diligent scientific research performed by Gencor Pacific, a global nutraceutical leader deeply rooted in the traditions of Ayurvedic medicine. Testofen has high concentrations of a specific group of saponin glycosides isolated and characterized exclusively by Gencor scientists. These compounds, called fenusides, are the subject of ongoing research, which Gencor believes will continue to support Fenugreek's testosterone -promoting benefits. In Ayurveda, Fenugreek is valued mostly for its effects on blood sugar and GI health. But many practitioners also recognize its benefits for hormonal support, especially its effects on testosterone, which appeared to enhance libido in both men and women.

God Bless,

Dan

Monday, April 29, 2013

More on Testosterone

Why do I keep harping on testosterone? Good question. To me is is personal, however I recognize that for many type 2 diabetics out there and even those who aren't diabetic as we get older we realize it plays an important role in our bodies.

Here are some foods that have been proven to boost testosterone. They work best when combined with some heavy duty physical exercise including some weight bearing exercises (I.E. squats, bench presses, pull ups, chin ups, push ups etc.) I say that because #1, it is TRUE and #2, you will enjoy your later years if you give it your best shot to get in shape. You might be thinking that, HEY are you nuts..........I haven't done a push up or a pull up, or picked up the dumb bells etc. since high school and it wasn't my fondest memory when I did do it. That's OK. I worked my way up in less than 30 days from ZERO push ups to doing 200 a day once a week and 100 every other day. My ONLY reason for stating that is ENCOURAGEMENT. You can achieve what your mind can believe. A 1000 mile journey starts with the first step.

List of foods to help boost your body's own production of testosterone:

Eggs (hard boiled, egg salad, eggs in your salad, fried, scrambled, poached, over easy)
Steak, roast beef, hamburger, organ meats (liver)
Pistachios, peanuts, walnuts, cashews etc.
Oysters, pumpkin seeds
Cabbage contains IC3-a phytochemical shown to increase testosterone
Garlic - contains allicin (CAUTION on this one as it can interfere with some diabetic meds and other prescription drugs such as blood pressure meds)
Oats - try Quaker Oats for Breakfast
Avacado
Salmon - I LIKE canned salmon
Fruits and veggies ( I LIKE green smoothies - see blog labels on green smoothies)

Dan

“It is far more important to know what person the disease has than what disease the person has.” 
― Hippocrates

KEEP a sense of humor about things:

Did you hear about the guy who was walking down the street with one foot on the sidewalk and the other on the street? Another man observing him said, "Sir you are obviously DRUNK!"

Thank God, the man said, "I thought I was crippled"




Friday, April 26, 2013

Testosterone Boosters

I am still doing research into boosting testosterone levels. As mentioned I am 65, a type 2 Diabetic, fairly physically active and I get more than adequate levels of Vitamin D3, Zinc, magnesium and other important vitamins and minerals, along with adequate protein from natural sources and a daily shot of WHEY protein shakes. Despite my efforts, my last testosterone test showed me at 282 which is below the LOW NORMAL scale of 366. Even the 282 number was UP from the prior 3 month reading, however everything I am doing is still NOT enough apparently. I am back to doing squats with the dumb bells as of yesterday after a hiatus of several months because of a left knee injury a couple of years ago. The knee is no longer bothering me so I am back to doing the squats in addition to pull ups, chin ups, abdominal exercises, stretching, interval fast and normal pace walking, throwing some (raw) and lightly sauteed onions with butter into the mix. I over did the revisited squats with dumb bells yesterday so YES I am sore today, however I am working out a NEW routine to incorporate weights along with the squats and trying to re-balance my exercise routine to include all muscle groups. For some time now, I have been doing 100 to sometimes 150 push ups every other day and walking for 1/2 hour to 45 Min's several times a week. Life is a balancing act and at my age, I am not about to jump into bench pressing or doing deep squats with HEAVY weights, especially without a spotter. I also can't afford to fall or pull a muscle, or slip a disc etc.

That being said, I have neglected the legs in my routine other than the walking I do, so I am going to aggressively work those with the dumb bell squats every other day. I am going to cut back on the push ups to 50 or 75 every other day and incorporate some overhead dumb bell exercises and perhaps some light bench pressing  in the 80-100 pound range (at least at FIRST - and maybe work up to 150 pounds without a spotter).

That still leaves me below low normal in my T. readings and am still looking at all options EXCEPT the creams and topical gels etc. after a terrible reaction with my blood pressure to Androgel 1.62 about 1.5 years ago.

I find it fascinating how complex and intricate our bodies really are and how all the parts work together. I think it is wrong to try and TREAT just one aspect of illness without taking a well rounded approach to exercise, supplements, eating right etc.

I Corinthians 12:12-25 NIV


12Just as a body, though one, has many parts, but all its many parts form one body, so it is with Christ. 13For we were all baptized byc one Spirit so as to form one body—whether Jews or Gentiles, slave or free—and we were all given the one Spirit to drink. 14Even so the body is not made up of one part but of many.
15Now if the foot should say, “Because I am not a hand, I do not belong to the body,” it would not for that reason stop being part of the body. 16And if the ear should say, “Because I am not an eye, I do not belong to the body,” it would not for that reason stop being part of the body. 17If the whole body were an eye, where would the sense of hearing be? If the whole body were an ear, where would the sense of smell be? 18But in fact God has placed the parts in the body, every one of them, just as he wanted them to be. 19If they were all one part, where would the body be? 20As it is, there are many parts, but one body.
21The eye cannot say to the hand, “I don’t need you!” And the head cannot say to the feet, “I don’t need you!” 22On the contrary, those parts of the body that seem to be weaker are indispensable, 23and the parts that we think are less honorable we treat with special honor. And the parts that are unpresentable are treated with special modesty, 24while our presentable parts need no special treatment. But God has put the body together, giving greater honor to the parts that lacked it, 25so that there should be no division in the body, but that its parts should have equal concern for each other. 26If one part suffers, every part suffers with it; if one part is honored, every part rejoices with it.




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Replenish Testerone Naturally
Replenish Testosterone Naturally
Plant extracts favorably alter hormone metabolism and improve sexual desire in men
Through a variety of mechanisms, aging men suffer from the dual effects of having too little testosterone and excess estrogen. The result is a testosterone/ estrogen imbalance that can severely inhibit sexual desire and performance. In youth, low amounts of estrogen are used to turn off the powerful cell-stimulating effects of testosterone. As estrogen levels increase with age, testosterone cell stimulation may be locked in the "off" position, thus reducing sexual arousal and sensation and causing the common loss of libido so common in aging men.
The genital/pelvic region is packed with testosterone receptors that are ultra-sensitive to free testosterone-induced sexual stimulation. Clinical studies using testosterone injections, creams or patches have not always provided a long-lasting libido enhancing effect in aging men.
We now know why. Aging men sometimes convert testosterone to estrogen. The estrogen is then taken up by testosterone receptor sites in cells throughout the body. When an estrogen molecule occupies a testosterone receptor site on a cell membrane, it blocks the ability of serum testosterone to induce a healthy hormonal signal. It does not matter how much serum free testosterone is available if excess estrogen is competing for the same cellular receptor sites.
Testosterone is a hormone responsible for sex drive in both men and women. For testosterone to promote youthful sexual interest, satisfaction and performance, it must be freely available to cell receptor sites in the brain, the nerves, muscles and genitals. As people age, testosterone becomes bound to serum globulin and is not available to the cell receptor sites were it is needed to initiate sex stimulating centers in the brain. The component in the blood that renders free testosterone inactive is called sex hormone-binding globulin (SHBG). Excess estrogen can increase the production of SHBG and block testosterone-receptor sites. This means there are two mechanisms by which excess estrogen interferes with sex dive in aging males.
For testosterone to produce long-lasting libido enhancing effects, it must be kept in the "free" form in the bloodstream. Bound testosterone is not able to be picked up by testosterone receptors on cell membranes. For aging men, it is desirable to suppress excess levels of SHBG and estrogen while boosting free testosterone to the level of a young man. There is now a natural way of modulating testosterone and estrogen levels in aging men that does not require expensive prescription drugs.
Restoring youthful hormone balance can have a significant impact on male sexuality. To reiterate, the hormone modulation objectives that most aging men need to facilitate sexual rejuvenation involves an increase in "free" testosterone coupled by a decrease in both estrogen and SHGD levels.
Testosterone Chart
Increasing testosterone by suppressing excess estrogen
For many men, a safe and easy way to increase free testosterone is to prevent it from being converted (aromatized) into excess estrogen. Too much estrogen plays havoc with a man's sex life by binding to testosterone receptor sites and may contribute to the over-production of SHBG. SHBG binds free testosterone in a way that makes it unavailable to receptor sites in the brain, nerves and genitals.
Estrogen overload is a serious problem in aging men. One report showed that estrogen levels of the average 54-year-old man are higher than those of the average 59-year-old woman. Estrogen is a necessary hormone for men, but too much causes a wide range of health problems. High serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, thereby slowing the natural production of testosterone.
Based on the multiple deleterious effects of excess estrogen in men, aggressive actions should be taken to reduce estrogen to a safe range. To determine if estrogen levels are too high, men are encouraged to have their blood tested for estradiol. If the blood test results show estradiol levels are greater than 30 pg/mL, men should consider radical lifestyle changes, and/or taking an aromatase-inhibiting nutrient or drug.
A numerical example of the effects of a nutritional aromatase inhibitor can be seen on one of the subjects in the pilot studies whose initial serum estradiol level was a high 54 and free testosterone a moderately low 14.4. After only 30 days on a nutritional aromatase inhibitor, estradiol levels fell to 36 (from 54) and free testosterone levels increased to 22.5 (from 14.4). In this pilot study, funded by The Life Extension Foundation, 9 of 10 test subjects showed a significant decline in excess estrogen levels when several herbal extracts were combined. These kinds of results show how some men reduce excess estrogen while boosting free testosterone.
Herbs and male sexual potency
There are herbal extracts that have been shown to either increase or decrease testosterone levels.
Conversely, herbs that increase free testosterone and suppress excess estrogen are highly desirable for healthy men over age 40 who suffer the premature aging effects of a testosterone deficit, including loss of libido. We discuss some of these herbal extracts here.
Chrysin
A bioflavonoid called chrysin has shown potential as a natural aromatase-inhibitor. Chrysin can be extracted from various plants. Body builders have used it as a testosterone boosting supplement. The problem with chrysin is that because of its poor absorption into the bloodstream, it has not produced the testosterone enhancing effects users expect. In a study published in Biochemical Pharmacology (1999, Vol.58), the specific mechanisms of chrysin's absorption impairment were identified, which infers that the addition of a pepper extract (piperine) could significantly enhance the bioavailability of chrysin. Pilot studies have found that when chrysin is combined with piperine, reductions in serum estrogen (estradiol) and increases in total and free testosterone result in 30 days. Aromatase-inhibiting drugs are used to treat women with estrogen-dependant breast cancers. The rationale for this therapy is that estrogen is produced by fat cells via a process known as aromatization. Aging men often have excess aromatase enzyme activity, and the result is that too much of their testosterone is "aromatized" into estrogen. In a study published in the Journal of Steroid Biochemical Molecular Biology (1993;Vol 46, No 3), chrysin and 10 other flavonoids were compared to an aromatase-inhibiting drug (aminoglutethimide). The study tested the aromatase-inhibiting effects of these natural flavonoids (such as genistein, rutin, tea catechins, etc.) in human fat cell cultures. Chrysin was the most potent aromatase-inhibitor, and was shown to be similar in potency and effectiveness to the aromatase-inhibiting drug. The scientists conducting the study concluded by stating that the aromatase-inhibiting effects of certain flavonoids may contribute to the cancer preventive effects of plant-based diets. Two recent studies have identified specific mechanisms by which chrysin inhibits aromatase in human cells. These studies demonstrate that chrysin is a more potent inhibitor of the aromatase enzyme than phyto-estrogens and other flavonoids that are known to have aromatase-inhibiting properties (Arch Pharm Res 1999 Jun;22(3):309-12; J Steroid Biochem Mol Biol 1997 Apr;61(3-6):107-15). The purpose of these studies was to ascertain which fruits and vegetables should be included in the diet of postmenopausal women to reduce the incidence of breast cancer. Excess levels of mutagenic forms of estrogen have been linked to a greater risk of breast cancer, and scientists are studying dietary means of naturally reducing levels of these dangerous estrogens. Flavonoids such as chrysin are of considerable interest because they suppress excess estrogen via their aromatase-inhibiting properties. While this cancer preventing effect is most important for women, inhibiting aromatase in aging men has tremendous potential for naturally suppressing excess estrogen while boosting low levels of testosterone to a youthful state.
Since chrysin is not a patentable drug, don't expect to see a lot of human research documenting its effects. There are lots of FDA approved drugs that inhibit aromatase (such as Arimidex), and there is not much economic interest in finding natural ways of replacing these drugs. While prescription aromatase-inhibiting drugs are relatively free of side effects, aging men who are seeking to gain control over their sex hormone levels often prefer natural sources, rather than trying to convince a physician to prescribe a drug (such as Arimidex) that is not yet approved by the FDA as an anti-aging therapy. (Arimidex is prescribed to estrogen-dependant breast cancer patients to prevent testosterone and other hormones in the body from converting, i.e. aromatasing, into estrogen.)
An advantage to using plant extracts to boost testosterone in lieu of drugs is that the plant extracts have ancillary health benefits. Chrysin, for example, is a potent antioxidant that possesses vitamin-like effects in the body. It has been shown to induce an anti-inflammatory effect, possibly through inhibition of the enzymes 5-lipoxygenase and cyclooxygenase inflammation pathways. Aging is being increasingly viewed as a pro-inflammatory process, and agents that inhibit chronic inflammation may protect against diseases as diverse as atherosclerosis, senility and aortic valve stenosis. Chrysin is one of many flavonoids being studied as a phyto-extract that may prevent some forms of cancer. If chrysin can boost free testosterone in the aging male by inhibiting the aromatase enzyme, this would provide men with a low cost natural supplement that could provide the dual anti-aging benefits of testosterone replacement and aromatase-inhibiting drug therapy.
As previously discussed, boosting free testosterone levels can have a dramatic effect on sex drive, performance and satisfaction. Pilot studies indicate that chrysin increases total and free testosterone levels in the majority of men who take it with piperine.
Chrysin has one other property that could add to its libido-enhancing potential. A major cause of sexual dissatisfaction among men is work-related stress and anxiety. Another problem some men have is "sexual performance anxiety" that prevents them from being able to achieve erections when they are expected to. In a study published in Pharmacology Biochemistry and Behavior (1994, Vol 47), mice were injected with diazepam (Valium), chrysin or placebo to evaluate the effects these substances had on anxiety and performance levels. Chrysin was shown to produce anti-anxiety effects comparable with diazepam, but without sedation and muscle relaxation. In other words, chrysin produced a relaxing effect in the brain, but with no impairment of motor activity. The mechanism of action of chrysin was compared to diazepam, and it was shown that unlike diazepam, chrysin can reduce anxiety without inducing the common side-effects associated with benzodiazepine drugs.
A common problem with benzodiazepine drugs is memory impairment. In a study published in a 1997 issue of Pharmacology Biochemistry and Behavior (Vol 58, No 4), chrysin displayed potent anti-anxiety effects in rats, but did not interfere with cognitive performance. In this study, diazepam was shown to inhibit neurological function, but chrysin (and other anti-anxiety flavonoids) had no effect on training or test session performance. The scientists conducting this study pointed out that chrysin selectively inhibits anxiety in the brain but, unlike diazepam, does not induce the cognitive impairment.
Chrysin may therefore offer libido-enhancing effects in the aging male by:
- Increasing free testosterone, - Decreasing excess estrogen, - Producing a safe anti-anxiety effect.
Chrysin is being sold to body builders by commercial supplement companies that do not know if their product is favorably modulating testosterone and estrogen levels in men. The Life Extension Foundation, on the other hand, has conducted meticulous studies to evaluate the effects of chrysin (combined with piperine to facilitate absorption) on aging men. These studies have produced some impressive preliminary data, and ongoing research will be reported in future issues of Life Extension magazine.
Nettle
About 90% of testosterone is produced by the testes, the remainder by the adrenal glands. Testosterone functions as an aphrodisiac hormone in brains cells, and as an anabolic hormone in the development of bone and skeletal muscle. But testosterone that becomes bound to serum globulin is not available to cell receptor sites and fails to induce a libido effect. It is, therefore, desirable to increase levels of "free testosterone" in order to ignite sexual arousal in the brain.
As discussed already, a hormone that controls levels of free testosterone is called sex hormone-binding globulin (SHBG). When testosterone binds to SHBG, it loses its biological activity and becomes known as "bound testosterone," as opposed to the desirable "free testosterone." As men age past year 45, SHBG's binding capacity increases almost dramatically-by 40% on average-and coincides with the age-associated loss of libido.
Some studies show that the decline in sexual interest with advancing age is not always due to the amount of testosterone produced, but rather to the increased binding of testosterone to globulin by SHBG. This explains why some older men who are on testosterone replacement therapy do not report a long-term aphrodisiac effect. That is, the artificially administered testosterone becomes bound by SHBG, and is not bioavailable to cellular receptor sites where it would normally produce a libido-enhancing effect.
It should be noted that the liver also causes testosterone to bind to globulin. This liver-induced binding of testosterone is worsened by the use of sedatives, anti-hypertensives, tranquilizers and alcoholic beverages. The overuse of drugs and alcohol could explain why some men do not experience a libido-enhancing effect when consuming drugs and plant-based aphrodisiacs. An interesting review, "How Desire Dies" (Nature, 381/6584, 1996), discusses how frequently prescribed drugs, such as beta-blockers and antidepressants, cause sexual dysfunction. Prescription drugs of all sorts have been linked to inhibition of libido.
Logically, one way of increasing libido in older men would be to block the testosterone-binding effects of SHBG. This would leave more testosterone in its free, sexually activating form.
A highly concentrated extract from the nettle root provides a unique mechanism for increasing levels of free testosterone. Recent European research has identified constituents of nettle root that bind to SHBG in place of testosterone, thus reducing SHBG's binding of free testosterone. As the authors of one study state, these constituents of nettle root "may influence the blood level of free, i.e. active, steroid hormones by displacing them from the SHBG bindings site."
The prostate gland also benefits from nettle root. In Germany, nettle root has been used as a treatment for benign prostatic hyperplasia (enlargement of the prostate gland) for decades. A metabolite of testosterone called dihydrotestosterone (DHT) stimulates prostate growth, leading to enlargement. Nettle root inhibits the binding of DHT to attachment sites on the prostate membrane.
Nettle extracts also inhibit enzymes such as 5 alpha reductase that cause testosterone to convert to DHT. It is the DHT metabolite of testosterone that is known to cause benign prostate enlargement, excess facial hair and hair loss at the top of the head.
Muira puama
French scientists have identified an herbal extract that has shown libido enhancing effects in two human clinical studies. Muira puama comes from the stems and roots of the Ptychopetalum olacoides plant, and is widely used in the Amazon region of South America as an aphrodisiac, tonic and cure for rheumatism and muscle paralysis.
Muira puama has been the subject of two published clinical studies conducted by Dr. Jacques Waynberg, an eminent medical sexologist and author of 10 books on the subject. The first study, conducted at the Institute of Sexology in Paris under Waynberg's supervision, was reported in the November 1994 issue of The American Journal of Natural Medicine. The study population consisted of 262 men complaining of lack of sexual desire, or inability to attain or maintain erection. After two weeks, 62 percent of patients with loss of libido rated the treatment as having a dynamic effect, while 52 percent of patients with erectile dysfunction rated the treatment as beneficial. The article goes on to compare muira puama favorably to yohimbine, stating, "Muira puama may provide better results than yohimbine without side effects."
Dr. Waynberg's second study, entitled "Male Sexual Asthenia," focused on sexual difficulties associated with asthenia, a deficiency state characterized by fatigue, loss of strength, or debility, all symptoms of a testosterone deficiency. The study population consisted of 100 men over 18 years of age who complained of impotence or loss of libido, or both. A total of 94 men completed the study and were evaluated. Muira puama treatment led to significantly increased frequency of intercourse for 66% of couples. Of the 46 men who complained of loss of desire, 70% reported intensification of libido. The stability of erection during intercourse was restored in 55% of patients and 66% of men reported a reduction in fatigue. Other beneficial effects included improvement in sleep and morning erections.
Treatment with muira puama was much more effective in cases with the least psychosomatic involvement. Of the 26 men diagnosed with common sexual asthenia without noticeable sign of psychosomatic disorder, the treatment was effective for asthenia in 100% of cases, the lack of libido in 85% of cases, and for inability of coital erection in 90% of cases.
The latter finding confirms that broad tonic action of muira puama on conditions of fatigue and stress related sexual dysfunction. Since muira puama is not an artificial stimulant, it fortifies the system over a period of time. Some men report increased vitality within two weeks, while the full effects build over several weeks.
Dr. Waynberg notes that his toxicology studies and observations corroborate the conclusions of the scientific literature on the absence of toxicity of muira puama, which is well tolerated by men in general good health.
One of the earliest scientific studies of muira puama was conducted by another French doctor, Dr. Rebourgeon. His research found the plant to be effective in "gastrointestinal and circulatory asthenia as well as impotence." Three of the most respected scientific authorities on medical herbalism recommend muira puama. In newly published books, James Duke, Ph.D., Chief of the United States Department of Agriculture's Medical Plant Laboratory, and Michael Murray, M.D., recommend muira puama for erectile dysfunction or lack of libido. In addition, Daniel Mowrey, Ph.D., states the following in his book Herbal Tonic Therapies (p. 358):
Few in number are the plants that seem to have a reliable reputation as true aphrodisiacs. . . . Snake oil remedies abound, and confusion, dishonesty and hyped-up placebo razzmatazz carry the day. Out of this mess, one plant, virtually unknown to most Americans, appears to have risen above the competition. The plant is called muira puama. And though not much is known scientifically about the plant, all indications would lead one to believe that here is a material with the potential for making an important and significant contribution to the health of the male reproductive system.
Based on the clinical reports documenting the libido and energy enhancing effects of muira puama, it is possible that this herb induces these positive changes by favorably altering the hormone balance in aging men, i.e. increases free testosterone and/or suppresses excess estrogen.
Putting it all together
Enhanced sexual enjoyment is of paramount importance to a great many people, increasingly so as we age. An enormous amount of published data documents the libido-enhancing effects that occur when testosterone is restored to a youthful level.
Testosterone is much more than a sex hormone. There are testosterone receptor sites in cells throughout the body, most notably in the brain and heart. Youthful protein synthesis for maintaining muscle mass and bone formation requires testosterone. Testosterone improves oxygen uptake throughout the body, helps control blood sugar, regulate cholesterol and maintain immune surveillance. The body requires testosterone to maintain youthful cardiac output and neurological function.
Men suffering from depression often have lower levels of testosterone than control subjects. For some men, elevating free testosterone levels could prove to be an effective anti-depressant therapy. There is a scientific basis for free testosterone levels being measured in men suffering from depression and replacement therapy initiated if free testosterone levels are low normal or below normal.
One of the most misunderstood hormones is testosterone. Body builders tarnished the reputation of testosterone by putting large amounts of synthetic testosterone drugs into their young bodies. Synthetic testosterone abuse can produce detrimental effects, but this has nothing to do with the benefits a man over age 40 can enjoy by properly restoring his natural testosterone to a youthful level.
The many health benefits of hormone modulation therapy in aging men is the subject of these books authored by highly respected medical doctors: Vitality and Potency, by Jonathan V. Wright, M.D. and Lane Lenard, Ph.D. and The Testosterone Syndrome, co-authored by Eugene Shippen, M.D. These books provide meticulous molecular details, along with many case histories relating to the sexual enhancing effects that occur when free testosterone is increased beyond normal "middle-aged" levels.
In the November 1999 issue of this publication, an in-depth article described complex pharmaceutical methods of increasing free testosterone using FDA approved drugs. Many members, however, inquired about natural ways of increasing testosterone while suppressing excess estrogen.
Ongoing research at The Life Extension Foundation has resulted in several plant extracts being identified that appear to increase free testosterone and suppress excess estrogen in most men. In addition, clinical studies on one of these plant extracts indicates a significant libido-enhancing effect in the majority of men in placebo-controlled trials.
Men over age 40 now have the option of using testosterone patches or creams that need to be prescribed by their physician, or they can try a new combination of plant extracts that have shown promising results.
Results from published studies continue to substantiate the critical role that testosterone plays in protecting against premature aging. Life Extension magazine readers will be kept informed on scientifically validated testosterone enhancing strategies in future issues.
Excess Estrogen and age-associated immune dysfunction
It is well known that aging results in the shrinkage of the thymus gland, along with a reduction in the secretion of thymic hormones and T-cells, all of which are essential for maintaining youthful immune synchronization.
A study published in the journal Immnological Reviews (1997, Vol 160) showed that excess estrogen may be the primary sex hormone responsible for age-induced thymic involution (shrinkage) and age-associated immune dysfunction. The name of this extensive study was "Thymic Aging and T-Cell Regeneration," and it suggested that hormone modulation was one way of accomplishing thymic regeneration.
A chapter from the 1998 textbook Principles and Practices of Geriatric Medicine entitled "Immunity and Aging" also discussed the role sex steroid hormones play in thymic involution.
These studies suggest that restoring youthful sex hormone profiles could assist in protecting against immune impairment caused by the shrinking thymus gland.
Hormone modulating nutrients: the studies
As described in the November 1999 issue of Life Extension magazine, there are testosterone drugs and estrogen suppressing drugs that can be prescribed by your doctor. Understandably, however, some people do not want to use drugs if nutrients can accomplish the same objective.
In order to ascertain the safety and efficacy of various nutrients that are purported to modulate male hormone levels, The Life Extension Foundation has been sponsoring clinical studies to assess the effects of specific supplements on blood levels of testosterone, estrogen, SHBG, etc.
The results from the first pilot study showed that nine out of 10 men experienced a significant reduction in serum estradiol (estrogen) levels after only thirty days, compared to baseline. In this brief study, total testosterone increased in seven out of 10 men, but free testosterone increased in only four of the 10 men studied. Other blood parameters were not statistically altered.
A more comprehensive study incorporating a different combination of nutrients resulted in 8 out of 8 men experiencing increases in free testosterone while levels of the undesirable SHBG declined in seven out of eight men, compared to baseline. Estrogen and other blood parameters were not significantly altered in this study.
A third study was undertaken to evaluate still another combination of nutrients. It revealed that after thirty days, 12 out of 17 men experienced an increase in total testosterone and 11 out of 17 showed an increase in free testosterone, compared to baseline. Again, other blood parameters were not significantly altered.
Clinical trials are ongoing, and are expected to continue into early year 2000.
Medical Testing
For the average male over age 40, increasing free testosterone can restore the sexual fire of youth. The only downside to increasing free testosterone levels to those of a healthy 21-year-old is the potential effects it may have on men with prostate cancer. Before embarking on a testosterone-enhancement program a baseline blood PSA test and a digital rectal exam taken to rule out existing prostate cancer. When using testosterone drugs, PSA blood tests should be taken every 30-45 days for the first five months to rule out hidden prostate cancer.
When using slower acting testosterone boosting nutritional supplements, PSA testing can be reduced to every 60-90 days for the first eight months. Remember, the preponderance of the published literature shows that increasing free testosterone does not increase the risk of cancer in healthy men, but those with existing prostate cancer should avoid testosterone boosting drugs and supplements


Here is some additional input for those of you struggling like I am with perhaps type 2 diabetes and the natural decline of testosterone because of your age. This is from one of my sources which is Life Extension Magazine of which I am a happy subscriber:

http://www.lef.org/magazine/mag2000/jan00-cover2.html